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TREATMENT & SURVIVAL

There currently is no cure for mesothelioma. The chance of recovery for a person with mesothelioma depends on several factors, including:

Size of the cancer
Location of the cancer
Spread of the cancer throughout the body (Stage)
Response to treatment
Appearance of the cells under a microscope
Age of the patient

Management of mesothelioma depends largely on the staging of the tumor. Early diagnosis and surgical intervention may lengthen life expectancy. Depending on the age and physical condition of the patient, however, surgery may not be a viable option. In addition to surgical options, radiation treatment and chemotherapy may be helpful in the overall therapeutic program. Pain management and home care are typical alternatives in the later stages of the disease. Supportive treatment of symptoms includes respiratory treatments, chest percussion and vibration, medication and oxygen.

Currently, doctors and researchers are attempting to find new and effective ways to treat mesothelioma. When a new treatment is discovered, it is tested in clinical trials to measure its effectiveness.

A treatment plan is devised depending upon the mesothelioma type, aggressiveness, primary location, and degree of local (rarely, distant) spread. Treatment for mesothelioma is either local (confined to one area) or systemic (throughout the entire body). The three main types of treatment for mesothelioma are surgery, radiation therapy, and chemotherapy. The goal of surgery is to remove cancer tissue from the body. The goal of radiation therapy is to kill cancer cells using x-ray radiation. The goal of chemotherapy is to shrink the cancer and minimize the chance that it will spread. A newer type of treatment called photodynamic therapy uses special drugs and light to kill cancer cells during surgery.

Here is some specific information on four common treatment options:

Surgery: The goal of surgery is to physically remove the cancer from the body. The doctor may remove part of the lining of the chest or abdomen and some of the tissue around it. Sometimes part of the diaphragm, the muscle below the lungs that helps with breathing, is also removed. Depending on how far the cancer has spread, a lung also may be removed. This operation is called pneumonectomy.

Radiation therapy: The goal of radiation therapy is to use high-energy x-rays to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external radiation therapy) or from putting materials that produce radiation (radioisotopes) through thin plastic tubes in the area where the cancer cells are found (internal radiation therapy). Radiation may be used after surgery or as the main treatment for a patient where surgery is not recommended. Radiation therapy may be very useful in relieving pain associated with mesothelioma.

Chemotherapy: The goal of chemotherapy is to use drugs to shrink the cancer while also reducing the chance that it will spread to other parts of the body. Chemotherapy may be taken by pill, or it may be put into the body by a needle in the vein or muscle. Chemotherapy is called a systemic treatment because the drug enters the bloodstream, travels through the body, and can kill cancer cells throughout the body. In mesothelioma, chemotherapy may be put directly into the chest (intrapleural chemotherapy).

Intraoperative photodynamic therapy: Intraoperative photodynamic therapy is a new type of treatment that uses special drugs and light to kill cancer cells during surgery. A drug that makes cancer cells more sensitive to light is injected into a vein several days before surgery. During surgery to remove as much of the cancer as possible, a special light is used to shine on the pleura. This treatment is being studied for early stages of mesothelioma in the chest.

Survival Rate
The chance of recovery for a person with mesothelioma depends on several factors, including the size and location of the cancer, how far the cancer has spread, how the cancer cells look under the microscope, how well the cancer responds to treatment, and the patient’s age and health. The average survival time is about one year. However, if the cancer is found early and treated aggressively, almost half of the patients whose cancer is found early reach the two-year mark, and about 20% survive five years.

The 5-year survival rate refers to the percent of patients who live at least 5 years after their cancer is diagnosed. Many of these patients live much longer than 5 years after diagnosis, and 5-year rates are used to produce a standard way of discussing prognosis. Five-year relative survival rates exclude from the calculations patients dying of other diseases, and are considered to be a more accurate way to describe the prognosis for patients with a particular type and stage of cancer. Of course, 5-year survival rates are based on patients diagnosed and initially treated more than 5 years ago. Improvements in treatment often result in a more favorable outlook for recently diagnosed patients.
Each individual case is unique and there is hope for every sufferer of mesothelioma. Talk to your doctor for details on your individual prognosis. For support and encouragement, keep family and friends close and visit our Resources page for a list of groups and organizations that can help you deal with your cancer.

If you think you’re mesothelioma could have been prevented, read about How to Make a Case against a former employer or asbestos manufacturer.

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